Mounjaro (tirzepatide) is often described in conversations about blood sugar and weight as a medication that “reduces appetite.” That is only part of the picture. To understand how Mounjaro works, it helps to look at the two hormone pathways targeted by tirzepatide: GIP and GLP-1. Tirzepatide activates receptors for both hormones, which means its effects involve multiple systems—including the pancreas, digestive tract, appetite regulation, and glucose metabolism. Here is what